Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV
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چکیده
منابع مشابه
Immune Cells in the Female Reproductive Tract
The female reproductive tract has two main functions: protection against microbial challenge and maintenance of pregnancy to term. The upper reproductive tract comprises the fallopian tubes and the uterus, including the endocervix, and the lower tract consists of the ectocervix and the vagina. Immune cells residing in the reproductive tract play contradictory roles: they maintain immunity again...
متن کاملSecretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract.
BACKGROUND Pro-inflammatory chemokines that attract and cytokines that activate immune cells contribute to normal physiological homeostasis in the female reproductive tract, and are needed to deal effectively with potential pathogenic microbes. Mucosal epithelial cells are capable of producing these factors that communicate with cells of the innate and adaptive immune systems. METHODS Epithel...
متن کاملGeneration of Human Female Reproductive Tract Epithelium from Human Embryonic Stem Cells
BACKGROUND Recent studies have identified stem/progenitor cells in human and mouse uterine epithelium, which are postulated to be responsible for tissue regeneration and proliferative disorders of human endometrium. These progenitor cells are thought to be derived from Müllerian duct (MD), the primordial female reproductive tract (FRT). METHODOLOGY/PRINCIPAL FINDINGS We have developed a model...
متن کاملLeptotrichia amnionii and the Female Reproductive Tract
create a niche for M. tuberculosis (10). Our hypothesis could be refuted or corroborated in several ways, for example, by a case-control study of HIV-negative patients infected with tuberculosis. If this study refutes our hypothesis, the idea that sex hormones play a direct role in the immune response to M. tuberculosis would be supported. Such findings might also provide possibilities for drug...
متن کاملAdipokines and the Female Reproductive Tract
It is well known that adipose tissue can influence puberty, sexual maturation, and fertility in different species. Adipose tissue secretes molecules called adipokines which most likely have an endocrine effect on reproductive function. It has been revealed over the last few years that adipokines are functionally implicated at all levels of the reproductive axis including the gonad and hypothala...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2016
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2016.72